San Diego named after Saint Didacus (Diego de Alcalá in Spanish), is the second-largest city in California and the ninth largest city in the United States, located along the Pacific Ocean on the west coast of the United States. The US Census Bureau estimates the city's population at 1,279,329 as of 2008. This coastal city is also the county seat of San Diego County as well as the economic center of the San Diego–Carlsbad–San Marcos metropolitan area. As of 2008, this metropolitan area is the 17th-largest in the United States with a population of 3,001,072 and the 38th-largest metropolitan area in the Americas when including Tijuana, Mexico. According to Forbes the city of San Diego ranks as the fifth wealthiest in the United States. San Diego's biggest industries are manufacturing, the military, and tourism.

Many popular museums, such as the San Diego Museum of Art, the San Diego Natural History Museum, the San Diego Museum of Man, and the Museum of Photographic Arts are located in Balboa Park. The Museum of Contemporary Art San Diego (MCASD) is located in an ocean front building in La Jolla and has a branch located at the Santa Fe Depot downtown. The Columbia district downtown is home to historic ship exhibits belonging to the San Diego Maritime Museum, headlined by the Star of India, as well as the unrelated San Diego Aircraft Carrier Museum featuring the USS Midway aircraft carrier.San Diego has a growing art scene. "Kettner Nights" at the Art and Design District in Little Italy has art and design exhibitions throughout many retail design stores and galleries on selected Friday nights. "Ray at Night" at North Park host a variety of small scale art galleries on the second Saturday evening of each month. La Jolla and nearby Solana Beach also have a variety of art galleries.The San Diego Symphony at Symphony Towers performs on a regular basis and is directed by Jahja Ling. The San Diego Opera at Civic Center Plaza, directed by Ian Campbell, was ranked by Opera America as one of the top 10 opera companies in the United States. Old Globe Theatre at Balboa Park produces about 15 plays and musicals annually. The La Jolla Playhouse at UCSD is directed by Christopher Ashley. Both the Old Globe Theatre and the La Jolla Playhouse have produced the world premieres of plays and musicals that have gone on to win Tony Awards[41] or nominations[42] on Broadway. The Joan B. Kroc Theatre at Kroc Center's Performing Arts Center is a 600-seat state-of-the-art theatre that hosts music, dance and theatre performances. The San Diego Repertory Theatre at the Lyceum Theatres in Horton Plaza produces a variety of plays and musicals. Other professional theatrical production companies include the Lyric Opera San Diego and the Starlight Theatre.

Tourism has affected the city's culture, as San Diego houses many tourist attractions, such as SeaWorld San Diego, Belmont amusement park, San Diego Zoo, and the nearby San Diego Wild Animal Park and Legoland California. San Diego's Spanish influence can be seen in the many historic sites across the city, such as the Spanish missions and Balboa Park. Cuisine in San Diego is diverse, and includes European-American, Mexican-American, and Asian-American cuisine. Annual events in San Diego include Comic-Con, San Diego/Del Mar Fair, and Street Scene Music Festival.More than 50 movies and a dozen TV shows have been filmed in San Diego, a tradition going back as far as 1898.